Heavy Water Slows the Gonyaulax Clock: A Test of the Hypothesis That D 2 O Affects Circadian Oscillations by Diminishing the Apparent Temperature
- 1 November 1974
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 71 (11) , 4389-4391
- https://doi.org/10.1073/pnas.71.11.4389
Abstract
To test the hypothesis that deuterium oxide acts in circadian systems by simulating a lower environmental temperature, the effects of D2O on Gonyaulax polyedra were examined, where the period of the circadian rhythm of bioluminescent glow in constant environmental conditions is shorter at 16.degree. C than at 22.degree. C, and the phase of the glow peak relative to a light-dark cycle is advanced at 16.degree. C relative to 22.degree. C. Addition of low concentrations of D2O to Gonyaulax did not produce the same effects on period and phase as lowering the temperature; the free running period is lengthened and the phase is delayed. In the Gonyaulax rhythm, the effect of added D2O probably is not equivalent to lowering the temperature.This publication has 11 references indexed in Scilit:
- Membrane model for the circadian clockNature, 1974
- On the Very Rapid Enhancement by D 2 O of the Temperature-Tolerance of Adult DrosophilaProceedings of the National Academy of Sciences, 1974
- General Homeostasis of the Frequency of Circadian OscillationsProceedings of the National Academy of Sciences, 1973
- A Differential Effect of Heavy Water on Temperature-Dependent and Temperature-Compensated Aspects of the Circadian System of Drosophila pseudoobscuraProceedings of the National Academy of Sciences, 1973
- A substrate-binding protein in the Gonyaulax bioluminescence reactionArchives of Biochemistry and Biophysics, 1971
- BIOCHEMISTRY OF RHYTHMIC SYSTEMS*Annals of the New York Academy of Sciences, 1962
- Biochemical Aspects of Rhythms: Phase Shifting by ChemicalsCold Spring Harbor Symposia on Quantitative Biology, 1960
- Effects of Temperature upon Diurnal RhythmsCold Spring Harbor Symposia on Quantitative Biology, 1960
- ON THE MECHANISM OF TEMPERATURE INDEPENDENCE IN A BIOLOGICAL CLOCKProceedings of the National Academy of Sciences, 1957
- ON TEMPERATURE INDEPENDENCE IN THE CLOCK SYSTEM CONTROLLING EMERGENCE TIME IN DROSOPHILAProceedings of the National Academy of Sciences, 1954