Meta-analysis of serotonin transporter polymorphisms and affective disorders
- 1 September 2004
- journal article
- research article
- Published by Wolters Kluwer Health in Psychiatric Genetics
- Vol. 14 (3) , 121-129
- https://doi.org/10.1097/00041444-200409000-00001
Abstract
Polymorphisms in the promoter region (5-HTTLPR) of the serotonin transporter and a variable number of tandem repeats polymorphism in the second intron have been widely studied. However, the results of association studies examining unipolar depression (MDD) or bipolar disorder depression (BPD) have been mixed. To precisely ascertain small associations with both polymorphisms, a meta-analysis was performed involving several thousand subjects, using random-effects modeling. For MDD, the effect of the 5-HTTLPR genotype was significant (χ2=6.1, PSKeywords
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