Effect of Adrenalectomy and Corticoid Replacement on Mammary Gland Growth in Rats.

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Abstract
Adrenalectomized-ovariectomized (ADRX-OVARX) rats were injected with 1 [mu]g estradiol benzoate (EB) and 3 mg progesterone (P) per day for 19 days. Groups included those maintained on 1% saline drinking water alone and with 100 [mu]g prednisone and 100, 250, or 1000 [mu]g hydro-cortisone acetate (HC) per day and on 250 [mu]g desoxycorticosterone acetate (DOCA) per day. Mammary growth was determined by DNA content of 6 posterior glands. Adrenocorticoids in absence of EB and P had no effect on mammary growth. Injection of EB and P plus 100 [mu]g prednisone or 100 or 250 [mu]g HC per day increased DNA significiantly above ADRX-OVARX group receiving EB and P plus saline only (P .01) and not significantly different from OVARX group receiving EB and P. Groups receiving 1 mg HC or 250 [mu]g DOCA per day plus EB and P had DNA levels similar to ADRX-OVARX group on EB and P plus saline. The role of adrenocorticoids in mammary growth is considered to be synergistic by action on general metabolism. The term "mammopoietic" is suggested to describe the adrenocortical effect on mammary growth.

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