THE RELATION OF ALKALOSIS TO PEPTIC ULCER

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Abstract
Since Sippy1described his method of treating gastric and duodenal ulcers with excessive alkaline therapy, various authors have stressed the danger of alkalosis resulting from this plan of treatment. Hardt and Rivers,2in reporting sixteen cases of alkalosis which occurred in patients treated by this method, stated that patients with duodenal ulcer and renal complications were more inclined to develop toxic manifestations. These findings were confirmed by Shattuck, Rohdenburg and Booher.3Gatewood and his co-workers,4however, in a series of forty-six patients with peptic ulcer treated by the Sippy method, found that there was no definite evidence that the alkalemia observed was productive of any renal change. Definite nephritis was not recognized in any patients in whom alkalosis later developed. He concluded that pyloric obstruction was obviously an important factor in the production of alkalosis. Venables5and Jordan6stated that pyloric obstruction and previously

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