The anaerobe‐mediated mutagenicity of 2‐nitrofluorene and 2‐aminofluorene for salmonella typhimurium

1 January 1980

journal article
research article
Published by Wiley in Environmental Mutagenesis

Vol. 2 (3) , 353-358
https://doi.org/10.1002/em.2860020305

Abstract

Anaerobic bacteria (Bacteroides fragilis, B vulgatus, and B thetaiotaomicron) possess the enzymic ability to convert 2‐nitrofluorene and 2‐aminofluorene to substances mutagenic for Salmonella typhimurium. If it be assumed that the active intermediate for both chemicals is 2‐hydroxylaminofluorene, then these bacteria possess reductive as well as oxidative capabilities.

Keywords

This publication has 9 references indexed in Scilit:

The demonstration of a cooperative action of bacterial and intestinal mucosa enzymes in the activation of mutagens
Biochemical and Biophysical Research Communications, 1979
Properties of the Ames salmonella mutants lodged in the gastrointestinal tract of gnotobiotic rats
The American Journal of Clinical Nutrition, 1977
Activation of a procarcinogen to a mutagen by cell-free extracts of anaerobic bacteria
Mutation Research/Environmental Mutagenesis and Related Subjects, 1977
Studies on the mutagenicity of nitrofurans in Salmonella typhimurium
Biochemical Pharmacology, 1977
Association of salmonella mutants with germ-free rats: Characterization of the reverse mutational response to 2-nitrofluorene
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1976
Activation of nitrofurantoin to a mutagen by rat liver nitroreductase
Biochemical Pharmacology, 1976
Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test
Mutation Research/Environmental Mutagenesis and Related Subjects, 1975
Association of salmonella mutants with germfree rats: site specific model to detect carcinogens as mutagens.
Proceedings of the National Academy of Sciences, 1975
Mutagenicity of metronidazole: Activation by mammalian liver microsomes
Biochemical and Biophysical Research Communications, 1975