Studies on chloride permeability of the skin ofLeptodactylus ocellatus: II. Na+ and Cl− effect of inward movements of Cl−

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Abstract
At low concentration (1mm) of Cl− in the outer solution, the influx of chloride through the isolated skin (J 13 Cl ) of the South American frogLeptodactylus ocellatus (L.) seems to be carried by two mechanisms: (i) a passive one that exhibits the characteristics of an exchange diffusion process, and (ii) an active penetration. Studies of the influx and efflux of chloride (J 13 Cl andJ 31 Cl ) indicate, that the presence of a high (107mm) concentration of Cl− in the outer solution activates the translocation of this ion through the cells. Studies of the unidirectional flux of Cl− across the outer barrier (J 12 Cl ) indicate that Na+ out stimulates the penetration of Cl− at this level. Cl− out, in turn, stimulates, theJ 12 Na , but this effect is only detected at low concentrations of Na+ out.