RENAL INVOLVEMENT IN ADULT GAUCHERS-DISEASE AFTER SPLENECTOMY
- 1 January 1979
- journal article
- research article
- Vol. 103 (9) , 440-445
Abstract
Gaucher''s disease with severe clinical and pathologic renal involvement is exceptionally rare. Severe renal involvement and proteinuria was described in a young black woman with Gaucher''s disease. The accumulation of glucocerebroside (Gaucher bodies) in glomerular mesangial and endothelial cells and in interstitial cells of the kidney is indicative of the phagocytic potential and the deficiency of glucocerebroside-cleaving enzyme in these cells. Severe proteinuria in this patient was attributed to the extensive glomerular involvement by Gaucher''s disease.This publication has 9 references indexed in Scilit:
- Unusual cardiac, renal and pulmonary involvement in Gaucher's diseaseThe American Journal of Medicine, 1978
- Differentiation of β-glucocerebrosidase from β-glucosidase in human tissues using sodium taurocholateArchives of Biochemistry and Biophysics, 1976
- The Long-Term Course of Poststreptococcal GlomerulonephritisAnnals of Internal Medicine, 1974
- GAUCHERʼS DISEASEThe Lancet Healthy Longevity, 1967
- CHRONIC GAUCHERS DISEASE - CLINICAL OBSERVATIONS ON 34 PATIENTS1965
- Observations on a patient with Gaucher's diseaseThe American Journal of Medicine, 1961
- The Submicroscopic Morphology of Gaucher CellsBlood, 1957
- GAUCHER'S DISEASE IN 29 CASES: HEMATOLOGIC COMPLICATIONS AND EFFECT OF SPLENECTOMYAnnals of Internal Medicine, 1954
- GAUCHERS DISEASE - A REVIEW, AND DISCUSSION OF 20 CASES1951