Variability in Response to Drugs
- 12 October 1974
- Vol. 4 (5936) , 91-94
- https://doi.org/10.1136/bmj.4.5936.91
Abstract
Variability in the response to drugs is due to three principal components—the disease, the responsiveness of tissues, and the concentration of the drug at its site of action (as reflected by its plasma concentration). The relative contributions of these components will differ not only for different drugs but also for different effects of the same drug. Rational drug therapy depends on knowledge of all three factors.Keywords
This publication has 39 references indexed in Scilit:
- INEQUAL DIGOXIN TABLETSThe Lancet, 1973
- TABLET DISINTEGRATION: POSSIBLE LINK WITH BIOLOGICAL AVAILABILITY OF DIGOXINThe Lancet, 1972
- PLASMA PROTEIN BINDING, PLASMA CONCENTRATIONS, AND EFFECTS OF DIPHENYLHYDANTOIN IN MAN*Annals of the New York Academy of Sciences, 1971
- Plasma Levels of Digoxin in Relation to ToxicityActa Pharmacologica et Toxicologica, 1971
- Controlled Trial of Prednisone in Adult Patients with the Nephrotic SyndromeBMJ, 1970
- Measurement of Digoxin in Plasma and its use in Diagnosis of Digoxin IntoxicationBMJ, 1969
- HEMODYNAMIC EFFECTS OF LIDOCAINEActa Medica Scandinavica, 1969
- Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compoundsLife Sciences, 1967
- Hypertensive vascular diseaseThe American Journal of Cardiology, 1967
- THE EFFECTS OF SPIRONOLACTONE AND CHLORTHALIDONE ON ARTERIAL PRESSUREThe Lancet, 1962