Mechanisms of Leukocyte Production and Release VIII Eosinophil and Neutrophil Kinetics in Rats

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Abstract
Eosinophil and neutrophil kinetics were compared in normal rats and in rats subjected to repeated leukocyte, particularly eosinophil, removal following a single injection of tritiated thymidine.Analysis of neutrophil labelling in normal rats provided data on neutrophil production which were in agreement with results of similar studies in dogs and in humans. Some phases of neutrophil life cycles (e.g., maturation time), appeared to be shorter than those of other animals. Labelled mature neutrophils were seen in the bone marrow as early as 16 hours after isotope administration.In normal rats eosinophil myelocyte turnover and maturation time were estimated as 3 days and 8–12 hours respectively. Labelled eosinophils were seen in the circulation 2 days after isotope injection. The turnover time of mature marrow eosinophils was approximated as 19 hours and that of circulating eosinophils as 4.5 days with a tissue life of 2–4 days.Rats subjected to leukocytapheresis seemed to exhibit a general acceleration of granulocytopoiesis, as indicated by a shortening of cell generation times and possibly also of maturation times.
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