Abnormal Platelet Aggregation in Severe Combined Immunodeficiency Disease with Adenosine Deaminase Deficiency
- 1 June 1978
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 39 (2) , 189-194
- https://doi.org/10.1111/j.1365-2141.1978.tb01088.x
Abstract
The platelets from a boy with adenosine deaminase deficiency-severe combined immunodeficiency disease (ADA-SCID) showed markedly subnormal aggregation in response to collagen and ADP. In contrast with normal platelets, ATP, AMP and adenosine had little effect in inhibiting ADP-induced aggregation of ADA-SCID platelets. These observations suggest that altered adenosine metabolism exists in ADA-SCID platelets.This publication has 10 references indexed in Scilit:
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