Effects of diltiazem on morphine-induced respiratory decline

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Abstract
The individual and combined effects of subcutaneous morphine and diltiazem, a calcium channel inhibitor, on arterial blood gases and pH were assessed in conscious Fischer‐344 rats. Morphine (4mg kg−1) produced hypercapnia, hypoxia and slight acidosis, as compared with control values. Diltiazem (10 mg kg−1) alone did not affect these parameters; however, it significantly delayed the onset of the aforementioned effects of morphine.