Incidence of Nelson's Syndrome After Adrenalectomy for Cushing's Disease in Children
- 1 December 1977
- journal article
- research article
- Published by American Medical Association (AMA) in American Journal of Diseases of Children
- Vol. 131 (12) , 1353-1356
- https://doi.org/10.1001/archpedi.1977.02120250035005
Abstract
• To establish the incidence of Nelson's syndrome in children treated with total bilateral adrenalectomy (TBA) for Cushing's disease, a survey was made of members of The Lawson Wilkins Pediatric Endocrine Society. Thirty-one patients aged 10 months to 16 years had been treated with TBA for Cushing's disease; one had been treated with ortho para prime isomer of dichlorodiphenyldichloroethane alone. Postadrenalectomy hyperpigmentation was reported in 18 patients. Sella enlargement was detected in eight patients (25%) after 1 to 5.5 years (mean, three years) post-TBA. Five of these patients have had documented pituitary adenomas to date. This incidence is higher than the adult figure of 10% to 16%. (Am J Dis Child131:1353-1356, 1977)This publication has 2 references indexed in Scilit:
- Radioimmunoassay of ACTH in plasmaJournal of Clinical Investigation, 1968
- CUSHING'S SYNDROME OCCURRING WITH PITUITARY CHROMOPHOBE TUMOURSActa Endocrinologica, 1959