Methyl-CCNU [1-(2-chloroethyl)-3,4-methylcyclohexyl-1-nitrosourea] (NSC-95441) was administered to patients with malignant melanoma in a split dose schedule. Nausea and vomiting were eliminated as clinical problems during therapy. Response rate to the drug seemed somewhat lower than the average of 3 previously reported disease oriented phase II trials, though the difference was not significant statistically. The time course of myelosuppression seemed comparable to that seen with a single dose schedule of administration.