NEUROMUSCULAR BLOCKING AND HYPOTENSIVE ACTIONS OF STREPTOMYCIN, AND THEIR REVERSAL

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Abstract
Large doses (100-200 mg) of streptomycin injected in 20 dogs anesthetized with chloralose or pentobarbital caused neuromuscular blockade. Marked arterial hypotension invariably occurred. In all of 4 dogs, pholedrine restored and maintained blood pressure, but the amplitude of respiration and tibialis twitch still decreased. Neostigmine led to a slow and incomplete revovery to twitch response and little increase in blood pressure. CaCl2 alone, and after neostigmine, caused a quick and complete recovery of twitch response and restored the blood pressure. Small doses of CaCl2 may be useful clinically as an antidote.