Peroxidase Activity and Iodide Uptake in Hormone-Responsive and Hormone-Independent GR Mouse Mammary Tumors2
- 1 April 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 62 (4) , 1031-1034
- https://doi.org/10.1093/jnci/62.4.1031
Abstract
Transplanted mammary tumors growing in the inbred GR/AFlb mouse were assayed for peroxidase activity and ability to concentrate injected 125l. Both tumor peroxidase activity and iodide uptake were about ten times greater in the hormoneresponsive (HR) tumors than in the hormone-independent tumors. However, although peroxidases are known for their ability to participate in the iodination of proteins, over 90% of the radioactive iodine found in the tumors was shown to be free iodide. This finding suggests that these two parameters may be independent of each other, but both are higher in HR tumors.Keywords
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