Improving Elution and Displacement Ion-Exchange Chromatography by Adjusting Eluent and Displacer Affinities
- 1 November 1986
- journal article
- research article
- Published by Taylor & Francis in Separation Science and Technology
- Vol. 21 (9) , 873-885
- https://doi.org/10.1080/01496398608058384
Abstract
Multicomponent interference in ion-exchange chromatography is examined in this paper. A multicomponent chromatography theory is used to analyze the effect of eluent affinity in elution chromatography, and displacer and presaturant affinity in displacement chromatography. The eluent should have an affinity between those of the feed components and near the strongest affinity species. In displacement chromatography, the displacer and presaturant affinities should bracket those of the desired products as closely as possible. Displacement chromatography produces pure product peaks, although the feed throughput is larger for elution chromatography. These conclusions are also valid for adsorption chromatography.Keywords
This publication has 6 references indexed in Scilit:
- Role of the desorbent in bulk adsorption separationsChemical Engineering Science, 1985
- Production-Scale Adsorptive Separations of Liquid Mixtures by Simulated Moving-Bed TechnologySeparation Science and Technology, 1984
- Analysis of multicomponent separation by displacement developmentAIChE Journal, 1982
- On the theory of multicomponent chromatographyPhilosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences, 1970
- Hyperbolic systems of conservation laws IICommunications on Pure and Applied Mathematics, 1957
- The Theory of ChromatographyJournal of the American Chemical Society, 1943