Administration of Harmine and Imipramine Alters Creatine Kinase and Mitochondrial Respiratory Chain Activities in the Rat Brain

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Abstract
The present study evaluated mitochondrial respiratory chain and creatine kinase activities after administration of harmine (5, 10, and 15mg/kg) and imipramine (10, 20, and 30mg/kg) in rat brain. After acute treatment occurred an increase of creatine kinase in the prefrontal with imipramine (20 and 30mg/kg) and harmine in all doses, in the striatum with imipramine (20 and 30mg/kg) and harmine (5 and 10mg/kg); harmine (15mg/kg) decreased creatine kinase. In the chronic treatment occurred an increase of creatine kinase with imipramine (20mg/kg), harmine (5mg/kg) in the prefrontal with imipramine (20 and 30mg/kg) and harmine (5 and 10mg/kg) in the striatum. In the acute treatment, the complex I increased in the prefrontal with harmine (15mg/kg) and in the striatum with harmine (10mg/kg); the complex II decreased with imipramine (20 and 30mg/kg) in the striatum; the complex IV increased with imipramine (30mg/kg) in the striatum. In the chronic treatment, the complex I increased with harmine (5mg/kg) in the prefrontal; the complex II increased with imipramine (20mg/kg) in the prefrontal; the complex IV increased with harmine (5mg/kg) in the striatum. Finally, these findings further support the hypothesis that harmine and imipramine could be involved in mitochondrial function.
Funding Information
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico