Methoxyflurane and Liver Function

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Abstract
THE MANY ADVANTAGES offered by the fluorinated volatile anesthetic agents have lead to their universal acceptance. In spite of this acceptance, however, there has been continuing concern that these halogenated compounds may produce adverse effects upon the liver. The justification for this concern has been the recent reports of serious hepatotoxicity attributed to, but not proven to be due to, halothane.1-3 A review of the literature on methoxyflurane indicates that there are few critical data pertaining to liver function after the use of this anesthetic. Accordingly, it seemed appropriate to apply a battery of hepatic function tests preand postoperatively to a group of patients anesthetized with this halogenated ether. Patients Studied Sixty-one patients, ranging in age from 15 to 75 years (average 46.2 years), divided between the sexes (33 females and 28 males) and all white were operated under methoxyflurane anesthesia. The age distribution by decade was 10 to

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