PLATELET PRODUCTION AFTER ADMINISTRATION OF ANTI-PLATELET SERUM AND 5-FLUOROURACIL

  • 1 January 1980
    • journal article
    • research article
    • Vol. 55  (1) , 164-166
Abstract
Although 5-fluorouracil induces relatively minimal thrombocytopenia in mice compared with antiplatelet serum, the ensuing rebound thrombocytosis was much greater. It also occurred several days later. Administration of 5-fluorouracil 24 h after antiplatelet serum suppressed the increase in platelets produced by antiplatelet serum, while the subsequent thrombocytosis was indistinguishable from that produced by 5-flourouracil alone. Thrombocytosis that occurred after 5-flourouracil originated from a class of primitive stem cells or early megakaryocyte precursors which were not killed by the drug. Thrombocytosis occurring after antiplatelet serum was derived from more mature precursor cells which were sensitive to 5-fluorouracil.