THE INFLUENCE OF SOME HORMONAL, DIETARY, AND TUMOR FACTORS ON LIVER CATALASE ACTIVITY IN RATS

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Abstract
Liver catalase activity can be reduced by the administration of cortisone or stilboestrol and by the production of anemia, as well as by the presence of a tumor in the host. All of these factors cause a disturbance of body growth. However, interference with growth produced by adrenalectomy or low protein diet is not associated with loss of liver catalase activity. The loss of liver catalase activity in tumor-bearing rats is associated frequently with an increase in liver size. But rats with large tumors may have small livers and still demonstrate the drop in catalase activity. It is suggested that the loss of liver catalase activity in tumor-bearing rats is not due to body growth disturbance or liver hypertrophy, and is produced in excess of such nonspecific factors as adrenal stimulation.