CB1-cannabinoid and μ-opioid receptor co-localization on postsynaptic target in the rat dorsal horn
- 1 December 2001
- journal article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 12 (17) , 3689-3692
- https://doi.org/10.1097/00001756-200112040-00017
Abstract
Cannabinoids and opioids interact in the control of nociception at the spinal level. Likely, several mechanisms are involved, with one of them being co-localization of cannabinoid and opioid receptors. In order to validate this hypothesis, a double labeling study of CB1 cannabinoid receptors and mu-opioid receptors in the dorsal horn of the rat spinal cord was performed. A strong co-localization of CB1 and mu-opioid receptors was observed in lamina II interneurons at the ultrastructural level. The physiological consequences of the co-localization are discussed.Keywords
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