TEMPORAL PATTERN FORMATION BY HETEROCHRONIC GENES
- 1 December 1997
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genetics
- Vol. 31 (1) , 611-634
- https://doi.org/10.1146/annurev.genet.31.1.611
Abstract
▪ Abstract Heterochrony describes the phylogenetic variation in the relative timing of major developmental events. Such heterochronic variation has been noted across phylogeny, including closely related species, suggesting that particular genetic loci control global aspects of developmental timing, and that variation at those loci may play important roles in evolutionary change. Genetic analyses of heterochronic mutations in the nematode Caenorhabditis elegans reveal that control of temporal patterning is analogous to the dedicated genetic pathways that control the patterning of the spatial axes in Drosophila and other metazoans. These pathways generate graded or binary levels of regulatory factors that pattern particular axes of the developing animal. C. elegans heterochronic genes constitute a regulatory cascade that both generates a temporal decrease in the level of the LIN-14 and LIN-28 proteins and responds to the changes in these gene activities to coordinate the temporal sequence of many cell fates...Keywords
This publication has 49 references indexed in Scilit:
- Post-embryonic cell lineages of the nematode, Caenorhabditis elegansPublished by Elsevier ,2004
- The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNACell, 1997
- A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation.Genes & Development, 1996
- Isolation of LUMINIDEPENDENS: a gene involved in the control of flowering time in Arabidopsis.Plant Cell, 1994
- The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Cell, 1993
- The origin of pattern and polarity in the Drosophila embryoCell, 1992
- Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.Genes & Development, 1991
- The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switchNature, 1989
- The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events.Genes & Development, 1987
- Constraint, flexibility, and phylogenetic history in the evolution of direct development in sea urchinsDevelopmental Biology, 1987