Biosynthesis of pulcherriminic acid

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Abstract
Candida pulcherrima was grown on a complex medium to which various compounds had been added to determine their effect on the biosynthesis of pulcherriminic acid. Most of the pulcherriminic acid synthesized by C. pulcherrima PRL2019 was derived from the L-[1-C14]leucine added to the medium. The cyclic dipeptide of L-leucine (cyclo-L-leucyl-L-leucyD was shown, by trapping experiments involving cyclo-leucyl-leucyl isomers, to be synthesized by strain PRL2019. Cyclo- L-leucyl-L-leucyl was derived from L-leucine and was converted into pulcherriminic acid. Cyclo-L-!eucyl-L-leucyl was a precursor of pulcherriminic acid in strain PRL2007 also. The results supported the hypothesis that pulcherriminic acid is derived from L-leucine and that cyclo-L-leucyl-L-leucyl is an intermediate in the biosynthesis.

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