IMMEDIATE (IGE-MEDIATED) SKIN TESTING IN DIAGNOSIS OF ALLERGIC DISEASE

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 41  (4) , 211-215
Abstract
Immediate (Ig[immunoglobulin]E-mediated) skin tests are widely used in the diagnosis of [human] allergic diseases. Skin tests correlated well with more specialized studies (RAST [radioallergosorbent test], histamine release and provocation tests) in the diagnosis of allergic disease. Lack of standardization and quantitation of biologic potency of allergens made critical comparison of skin test results impossible. Widely divergent opinions are held concerning the effect of anti-allergic drugs on skin tests. Apparently only antihistamines cause significant depression of skin reactivity. Therapy for asthma may be continued while diagnostic skin testing is in progress, avoiding the possible morbidity associated with discontinuing pharmacologic therapy.

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