THE EFFECTS OF CASTRATION AND TESTOSTERONE PROPIONATE ON THE STRIATED PERINEAL MUSCULATURE IN THE RAT

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Abstract
47 adult [male] rats of the Long-Evans strain were divided into 4 groups; normals, castrated, castrated treated with testosterone propionate, and normals treated with testosterone propionate. All animals were autopsied 35-45 days after beginning of expt. The perineal muscle complex, consisting of the bulbo cavernosus, ischio cavernosus, and levator ani, was dissected out, weighed, fixed and studied histologically. After histological study and statistical analysis it was concluded that castration caused a great size decrease of the striated perineal musculature, the greatest change being in fiber width. This was prevented by daily adm. of testosterone propionate, and adm. of testosterone propionate to normal rats caused a significant hypertrophy over the normal. In the other striated muscles no comparable changes were seen.

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