Synthesis of Morphine-3,6-di-β-D-glucuronide
- 1 October 1997
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1997 (10) , 1165-1168
- https://doi.org/10.1055/s-1997-3187
Abstract
The synthesis of morphine-3,6-di-β-D-glucuronide as the monolithium salt from a fully protected morphine-6-β-D-glucuronide 12 via selective 3-deacetylation followed by Lewis acid-catalyzed 3-glucuronidation, and stepwise deprotection with lithium hydroxide is described.Keywords
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