Risk of Venous Thromboembolism After Air Travel

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Abstract
VENOUS THROMBOEMBOLISM (VTE) is a multifactorial disease resulting from the interaction between genetic and environmental risk factors.1 The former includes abnormalities causing inherited thrombophilia, such as deficiencies of the naturally occurring anticoagulants antithrombin, protein C, protein S, and the gain-of-function mutations in genes encoding coagulation factor V (factor V Leiden) and prothrombin. The environmental, transient risk factors associated with an increased risk of VTE are cancer, recent surgery, pregnancy and puerperium, use of oral contraceptives, and prolonged immobilization.