A NEW HYPOTHESIS ON MEMORY - A POSSIBLE ROLE OF LOCAL CIRCUITS IN THE FORMATION OF THE MEMORY TRACE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 59  (4) , 224-229
Abstract
An hypothesis is proposed arguing that local circuits might work as biochemical units involved in the synthesis of macromolecules related to the memory processes. Specific sequences in the activation of local circuits should act as a template for the synthesis of particular memory molecules, which, in turn, may facilitate the repetition of the original sequence of bioelectrical signals (short-term memory). The resynthesis of the local memory molecules in cell body areas, their flow to terminal areas via axoplasmic transport and their possible passage to other nerve cells via transynaptic transport might be the basis of long-term memory. The role of diffuse neuronal systems (e.g., noradrenaline [norepinephrine] systems) is discussed in the frame of memory recall and consolidation. The suggested hypothesis can be represented in a very effective way by means of the graph theory.

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