Amantadine does not have antiviral activity against Borna disease virus
- 6 April 1997
- journal article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 142 (10) , 2035-2042
- https://doi.org/10.1007/s007050050220
Abstract
We have investigated the antiviral activity of amantadine (AD) against Borna disease virus (BDV) in several culture cell systems. We present evidence that AD, in the range 5 to 10 microM, does not have antiviral activity against BDV. Treatment of BDV infected cells with AD for six days caused neither a reduction in the number of infected cells, nor a decrease in steady state levels of BDV RNA or proteins. Moreover, treatment of cells with AD prior infection did not affect BDV multiplication, whereas influenza A virus yield was less than 1% with respect to that obtained in untreated control cells.Keywords
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