Cellular and Extracellular Spaces in Developing Rat Brain

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Abstract
DURING development of the central nervous system (CNS) both cellular and extracellular spaces and the permeability of the CNS to various substances undergo certain changes. For example, cytological studies have shown that both the number and the volume of glial cells increase with maturation whereas the number of neurons remains constant and only the neuronal volume increases.2,3It has also been shown that the brain extracellular space decreases during development.7,19Methods for studying the various physiological compartments of the CNS have been developed by Woodbury,20Reed and Woodbury,12and Reed et al.13The rate of entrance of radioactive substances such as sucrose, iodide, chloride, inulin, and bromide into the CNS and their volume of distribution were used to study the various physiological compartments of the brain and the interchange of substances between these compartments. However, such studies have been confined to adult animals and no