Human Placental 15-Hydroxyprostaglandin Dehydrogenase
- 1 March 1972
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (3) , 533-534
- https://doi.org/10.1073/pnas.69.3.533
Abstract
Normal, term, human placentas are a rich source of a 15-hydroxyprostaglandin dehydrogenase. The enzyme is extremely labile, and partial purification could be achieved only after stabilization with glycerol. The instability of the enzyme and its K m for NAD are indications that it is different from the 15-hydroxyprostaglandin dehydrogenase isolated from swine lung. Human placental tissue should provide a very useful source from which large amounts of highly purified 15-hydroxyprostaglandin dehydrogenase may be obtained.Keywords
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