Solute migration during granule drying
- 1 December 1974
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 26 (Supplement) , 24P-29P
- https://doi.org/10.1111/j.2042-7158.1974.tb10073.x
Abstract
Spherical granules of magnesium carbonate, incorporating polyvinylpyrrolidone (PVP) as granulating agent, have been dried at various temperatures under controlled conditions in a drying tunnel. At each drying temperature the rate of loss of moisture was continuously recorded. The PVP distribution, modulus of elasticity, Brinell hardness and friability of the granules were measured as a function both of moisture content and of depth from the granule surface. The radial distribution of PVP at different stages of the drying process and at three drying temperatures, and its effect on the physical properties of the granules, were thus found. This gave a picture of binder distribution within the granule and its effect on local strength as drying occurred and also of the overall change caused by alteration in drying temperature.Keywords
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