Human IgE Response to the Administration of Blood Components

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Abstract
43 adults from a renal dialysis unit staff have received regularly spaced γ‐globulin administrations for hepatitis B prophylaxis. Several blood samples were collected over a prolonged period of time (160 days). Following γ‐globulin administration, anti‐immunoglobulin antibodies of the IgE class were detected in 80% of this population, a fortnight after the first injection using serum absorptions on polymerized γ‐globulins or a specific inverse RAST method. The reactivity pattern of these IgE anti‐immunoglobulin antibodies was similar to that observed for the anti‐immunoglobulin antibodies with ‘limited specificity’ detected by passive hemagglutination, in that they reacted with only one of the immunoglobulins of the panel used for their detection. A decrease of the overall IgE levels was observed in 62% of the subjects for a prolonged period of time following γ‐globulin administration. This suggests a feedback regulation mechanism for the reagin production in man, as it has already been observed in animals. A high incidence of anti‐immunoglobulin antibodies of various classes was observed in this study. However, only a small number (4/43) of adverse reactions appeared following γ‐globulin administration. For some of these subjects, the presence of specific IgE anti‐immunoglobulin, detected by the inverse‐RAST technique, suggests a possible role of such antibodies in some intolerance reactions to γ‐globulin administration.