Factors Influencing Kanamycin Resistance in Gram-Negative Enteric Neonatal Sepsis

Abstract
Gram-negative enteric organisms are responsible for at least 50% of cases of neonatal septicemia.1,2 Because of the emergence of kanamycin-resistant organisms, gentamicin has become the aminoglycoside agent of choice in many neonatal intensive care units.1 Increased use of gentamicin, however, favors the development of gentamicin resistance,3 which has prompted interest in reducing reliance on gentamicin.

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