A conformational analysis of adriamycin based upon its 1H nuclear magnetic resonance spectrum in various solvents
- 1 October 1987
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 65 (10) , 2405-2410
- https://doi.org/10.1139/v87-401
Abstract
The solution conformation of adriamycin was studied by 1H nuclear magnetic resonance spectroscopy. The hydrochloride was found to be rigid on the nmr time scale in each of CDCl3, DMF-d7, and DMSO-d6. The sugar and D rings were found to have the same conformations as were found previously by X-ray crystallography. Similar results were found for the free base in DMF-d7 and CDCl3 solutions although the free base was found to be conformationally mobile in acetone-d6 and CD3OD solutions.This publication has 0 references indexed in Scilit: