REDUCED BETA-ADRENERGIC RESPONSIVENESS IN RATS TREATED WITH ESTROGENIC AGENTS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 197  (2) , 362-370
Abstract
Chronic treatment with ethynyl estradiol alone (48-50 .mu.g/kg per day) and in combination with several doses of norethynodrel either attenuated or prevented the increase in tail skin temperature accompanying s.c. administration of isoproterenol (200 .mu.g/kg b.wt. [body wt]) to male and female rats. Dietary administration of an oral contraceptive containing norethynodrel and mestranol (7.5 mg/kg of food) was accompanied by an attenuated response to isoproterenol. Attenuation of the tail skin temperature response was present in all groups after 3-5 wk of treatment but was detectable in the oral contraceptive-treated group after 1 wk of treatment. All steroids and combinations, except norethynodrel administered alone (154 .mu.g/kg per day), reduced body weight gain.

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