Human Endothelial Nitric Oxide Synthase Gene Delivery Promotes Angiogenesis in a Rat Model of Hindlimb Ischemia
- 1 August 2002
- journal article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 22 (8) , 1279-1285
- https://doi.org/10.1161/01.atv.0000026613.18742.67
Abstract
Objective— Endothelium-derived NO has been shown to mediate the mitogenic effect of vascular endothelial growth factor on cultured microvascular endothelium. To evaluate the role of endothelial NO synthase (eNOS) in angiogenesis in the ischemic hindlimb, we engineered an adenovirus containing human eNOS cDNA.Keywords
This publication has 18 references indexed in Scilit:
- Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeabilityProceedings of the National Academy of Sciences, 2001
- Nitric Oxide Induces Angiogenesis and Upregulates αvβ3 Integrin Expression on Endothelial CellsMicrovascular Research, 2000
- Rescue of Diabetes-Related Impairment of Angiogenesis by Intramuscular Gene Therapy with Adeno-VEGFThe American Journal of Pathology, 1999
- Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase.Journal of Clinical Investigation, 1998
- Efficient Construction of a Recombinant Adenovirus Vector by an ImprovedIn VitroLigation MethodHuman Gene Therapy, 1998
- Vascular Endothelial Growth Factor-C (VEGF-C/VEGF-2) Promotes Angiogenesis in the Setting of Tissue IschemiaThe American Journal of Pathology, 1998
- Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.Journal of Clinical Investigation, 1998
- Microangiographic assessment of collateral vessel formation following direct gene transfer of vascular endothelial growth factor in ratsCardiovascular Research, 1997
- Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis.Journal of Clinical Investigation, 1997
- Nitric Oxide Promotes DNA Synthesis and Cyclic GMP Formation in Endothelial Cells from Postcapillary VenulesBiochemical and Biophysical Research Communications, 1993