Abstract
In a double blind study involving 377 patients, the value of the serum carcinoembryonic antigen (CEA) assay as an adjunct to the radionuclide liver scan was assessed for detection of liver metastases. Fifty-seven patients studied by both methods had liver metastases. In 28 instances in which the results of both tests were in agreement, these results were diagnostic with regard to the presence or absence of hepatic involvement. The CEA assay suggested the presence of metastatic tumor in 8 of the 12 patients with false negative liver scans, proving to be a useful adjunct to liver scanning in the detection of hepatic metastasis.

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