Pathology of the intrinsic muscles of the larnyx

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Abstract
The intrinsic muscles of the larynx were exposed in 54 normal larynges derived from the autopsy series of a general hospital and submitted to microscopic examination. Muscle fiber alterations were found in all the posterior cricoarytenoid muscles in patients from 13 yr of age onwards. In .apprx. 1/2 of the patients, these changes included necrosis of segments of muscle fibers and secondary cellular reactions to this. In 3 cases of chronic autonomic failure with multiple system atrophy, the intrinsic laryngeal muscles were similarly examined. Both cases showed a marked gross and microscopic atrophy of the posterior cricoarytenoid muscles; there were also microscopic changes similar to those found in the normal population. The significance of the changes in the routine post-mortem larynges, the changes in the cases of chronic autonomic failure with multiple system atrophy and the relationship between the 2 are discussed.

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