Inhibition of Cytomegalovirus by Rifampin
- 1 May 1972
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 125 (5) , 552-555
- https://doi.org/10.1093/infdis/125.5.552
Abstract
Rifampin at a concentration of 150 μg/ml interfered with the replication of Davis, Kerr, and AD 169 strains of cytomegalovirus in Wi-38 cells. The replication of herpes-simplex virus (types 1 and 2) and Sindbis virus in the same cells was unaffected by a similar concentration of the antibiotic. Direct inactivation of the virus and interference with adsorption and release of the virus were excluded as possible mechanisms for the inhibitory effect.Keywords
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