THE RELATIVE POTENCIES OF THIOPENTONE, KETAMINE, PROPANIDID, ALPHAXALONE AND DIAZEPAM

Open Access

1 February 1979

journal article
research article
Published by Elsevier in British Journal of Anaesthesia

Vol. 51 (2) , 119-122
https://doi.org/10.1093/bja/51.2.119

Abstract

The potency of five i.v. anaesthetics (thiopentone, ketamine, alphaxalone (Althesin), propanidid and diazepam) was studied by determining the dose required to produce unconsciousness in 50% (UD₅₀) and 95% (UD₉₅) of patients. UD₅₀ and UD₉₅ were determined using the probit method. The effect of age on the anaesthetic requirement has been studied also. Relative to thiopentone, the potency was alphaxalone 9.22, diazepam 5.24, ketamine 4.37 and propanidid 1.006.