Identification of two new alleles HLA-DRB1*0312, DRB1*0432 and of a DRB3-negative DRB1*1313-positive haplotype
- 1 July 2000
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 56 (1) , 87-89
- https://doi.org/10.1034/j.1399-0039.2000.560112.x
Abstract
Two new HLA-DRB1 alleles were identified in the course of routine class II molecular typing in Dutch Caucasoid. HLA-DRB1*0312 is similar to *03011 except for codon 57 (GAT-->AGC). DRB1*0432 is similar to *0413 but with a mutation at position 215, changing codon 72 (CGG-->CAG; Arg-->Gln). This sequence has never before been identified at this position. A DRB3-negative DRB1*1313 haplotype was identified in an individual from Indonesia. Monoclonal antibodies against DR52 were nonreactive with lymphocytes of this individual. The DRB1*1313-DRB3-negative haplotype probably represents a recombination of DRB1*13 and *08 haplotypes where the sequences telomeric of HV1 are derived from the DRB3-negative DRB1*0803 haplotype.Keywords
This publication has 7 references indexed in Scilit:
- Nomenclature for factors of the HLA system, 1998Tissue Antigens, 1999
- Identification of the DRB1*1313 allele in a sibling pair.Tissue Antigens, 1997
- Nomenclature for factors of the HLA system. 1995Tissue Antigens, 1995
- Nomenclature for factors of the HLA system, 1994Human Immunology, 1994
- Biotinylated DRB sequence-specific oligonucleotides Comparison to serologic HLA-DR typing of organ donors in eurotransplantHuman Immunology, 1993
- Mhc-DRB diversity of the chimpanzee (Pan troglodytes)Immunogenetics, 1992
- HLA‐DR typing by PCR amplification with sequence‐specific primers (PCR‐SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor‐recipient matching in cadaveric transplantationTissue Antigens, 1992