Immunoepidemiologic Profile ofChlamydia trachomatisInfection: Importance of Heat‐Shock Protein 60 and Interferon‐γ

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Abstract
Epidemiological, animal, and in vitro investigations suggest that Chlamydia trachomatis infection engenders acquired immunity, the basis for which is incompletely defined, especially in humans. In a prospective cohort study of women at high risk for C. trachomatis infection, we found that, at baseline and after adjustment for age and other potential confounding variables, production of interferon-γ by peripheral-blood mononuclear cells (PBMCs) stimulated with chlamydia heat-shock protein 60 strongly correlated with protection against incident C. trachomatis infection. This investigation supports a direct role for C. trachomatis–specific immune responses in altering the risk of infection and suggests immune correlates of protection that are potentially useful in vaccine development

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