Preventing Neonatal Herpes — Current Strategies

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Abstract
DESPITE more than three decades of research, there is no effective strategy for preventing most cases of neonatal infection with herpes simplex virus (HSV). From the early 1970s until 1988, it was recommended that pregnant women with a history of genital HSV infection be screened close to term with weekly genital cultures and that those with evidence of infection at the time of delivery or a recent positive culture have a cesarean delivery to avoid fetal contact with the infected site. These practices are no longer recommended,1 2 3 4 because antepartum cultures do not reliably predict maternal infectivity at the time of . . .