Cisplatin neuropathy: clinical course and neurophysiological findings
- 1 January 1992
- journal article
- Published by Springer Nature in Zeitschrift für Neurologie
- Vol. 239 (4) , 199-204
- https://doi.org/10.1007/bf00839140
Abstract
Sixteen patients treated with cisplatin (CDDP) 40 mg/m2 on days 1–5 every 4 weeks for three courses (cumulative dose 600 mg/m2) were clinically and neurophysiologically tested before, during and 1, 3, 6, 9 and 12 months after CDDP administration. The first symptoms of polyneuropathy occurred in 4 of 9 patients after the second course (cumulative dose 400 mg/m2). One month after treatment 1 of 9 patients was asymptomatic, 5 complained of symptoms and 3 showed clinical and neurophysiological signs of polyneuropathy. Three months after CDDP all patients were affected. Clinical and neurophysiological signs of severity progression were noted up to 6 months after treatment with CDDP.Keywords
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