GRAFT-VERSUS-HOST-INDUCED IMMUNOSUPPRESSION

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Abstract
SUMMARY Using repeated antigenic challenges, attempts were made to stimulate an immune response in mice which had been rendered immunologically unresponsive by a graft-versus- host (GVH) reaction. F1 mice experiencing GVH reactions showed prolonged survival of subsequent third-party allografts, and failed to produce detectable antibodyforming cells following stimulation with sheep erythrocytes (SRBC). However, the injection of third-party bone marrow or kidney cells 13 days after the initiation of a GVH reaction caused a rapid rejection of subsequent skin allografts from the same third party. In contrast, multiple injections of SRBC into GVH-immunosuppressed animals failed to produce detectable antibody-forming cells. The results suggest that the GVH reaction completely suppresses the humoral immune response to SRBC but not the cell-mediated immune response to histocompatibility antigens.

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