Emergence of Ofloxacin Resistance in Mycobacterium tuberculosis Clinical Isolates from China as Determined by gyrA Mutation Analysis Using Denaturing High-Pressure Liquid Chromatography and DNA Sequencing
- 1 December 2006
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 44 (12) , 4566-4568
- https://doi.org/10.1128/jcm.01916-06
Abstract
A high rate of double point mutations in gyrA (56% of 87 ofloxacin-resistant Mycobacterium tuberculosis clinical isolates) indicates the emergence of fluoroquinolone resistance. This is the first report to describe denaturing high-pressure liquid chromatography analysis of mutations in gyrA of M. tuberculosis in a large number of clinical isolates.Keywords
This publication has 12 references indexed in Scilit:
- Temperature-mediated heteroduplex analysis for the detection of drug-resistant gene mutations in clinical isolates of Mycobacterium tuberculosis by denaturing HPLC, SURVEYOR nucleaseMicrobes and Infection, 2006
- Emergence of Fluoroquinolone Resistance in Mycobacterium tuberculosis during Continuously Dosed Moxifloxacin Monotherapy in a Mouse ModelAntimicrobial Agents and Chemotherapy, 2005
- Temperature-Mediated Heteroduplex Analysis for Detection of pncA Mutations Associated with Pyrazinamide Resistance and Differentiation between Mycobacterium tuberculosis and Mycobacterium bovis by Denaturing High- Performance Liquid ChromatographyJournal of Clinical Microbiology, 2004
- Multiplex PCR Amplimer Conformation Analysis for Rapid Detection of gyrA Mutations in Fluoroquinolone-Resistant Mycobacterium tuberculosis Clinical IsolatesAntimicrobial Agents and Chemotherapy, 2004
- Development of Fluoroquinolones as First-line Drugs for Tuberculosis—at Long Last!American Journal of Respiratory and Critical Care Medicine, 2003
- Fluoroquinolones, tuberculosis, and resistanceThe Lancet Infectious Diseases, 2003
- Temperature-Mediated Heteroduplex Analysis Performed by Using Denaturing High-Performance Liquid Chromatography To Identify Sequence Polymorphisms in Mycobacterium tuberculosis Complex OrganismsJournal of Clinical Microbiology, 2002
- Fluoroquinolone Resistance Associated with Specific Gyrase Mutations in Clinical Isolates of Multidrug-Resistant Mycobacterium tuberculosisThe Journal of Infectious Diseases, 1996
- Characterization of fluoroquinolone-resistant mutant strains of Mycobacterium tuberculosis selected in the laboratory and isolated from patientsAntimicrobial Agents and Chemotherapy, 1995
- Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutationsAntimicrobial Agents and Chemotherapy, 1994