TREATMENT OF ENTEROBIASIS (PINWORM INFESTATION) WITH DIPHENAN®, EGRESSIN® AND GENTIAN VIOLET

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Abstract
Pinworm infestations in children were diagnosed and followed for various periods by means of the cellulose-adhesive-tape technic, after which they were treated with diphenan®, egressin® or gentian violet and again followed for six days or longer. Twenty-four children were likewise tested but not treated. Diphenan® was found to have no detectable anthelmintic effect when given in high dosage to 53 children. Judged on the basis of cure-rate on 16 children, egressin® in relatively high dosage was of no value. It did, however, apparently decrease slightly the frequency of egg-deposition. A standard seven day course of gentian violet produced cures in at least 80% of 33 heavily infested children. The rate of spontaneous apparent cure was found to be related to the frequency of positive tests during the initial period of observation. Investigations of remedies for pinworm infestation yield more conclusive results if conducted on selected patients whose rate of spontaneous apparent cure is more or less predictably low.

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