A New Metabolic Pathway of Bromazepam Involving Attachment of a Methylthio Group
- 31 December 1975
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 6 (7) , 431-439
- https://doi.org/10.3109/00498257609151656
Abstract
1. The structures of three hitherto unidentified metabolites of bromazepam in the rat were elucidated using u.v., mass, n.m.r. and i.r. spectrometry. 2. All three metabolites contained a methylthio or corresponding oxidized group at the C-6′ position of the pyridyl moiety. 3. Quantitative analysis of the metabolites determined after administration of [14C]bromazepam to rat revealed that the three metabolites together comprised about 6 % of the total radioactivity excreted in the 24-h urine, or about 1 % of the dose.This publication has 10 references indexed in Scilit:
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