Urinary Total Hydroxyproline Excretion in Patients with Turner's Syndrome and Klinefelter's Syndrome

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Abstract
Urinary total hydroxyproline excretion in patients with Turner''s syndrome and Klinefelter''s syndrome was studied. Among the patients with Turner''s syndrome hydroxyproline excretion was relatively low in girls 11-14 yr old and somewhat increased in 14-17 yr age group. Above 17 yr of age urinary total hydroxyproline excretion was significantly higher than in the controls. In patients with Klinefelter''s syndrome below 11 yr and above 17 yr normal hydroxyproline values were observed. In three 16 yr old boys with 47,XXY karyotype, excretion of hydroxyproline with urine was significantly lower than in controls. Relatively low values of total hydroxyproline in urine of 11-14 yr old girls with Turner''s syndrome and decreased values in boys with Klinefelter''s syndrome result, most probably, from the absence of hormonal changes typical for puberty. Concentration of hydroxyproline in urine does not correlate with serum FSH and lutropin levels. It is not affected by the enhancement of changes in the bone system. The presented data encourage further studies on the connective tissue biochemistry in patients with numerical aberrations of sex chromosomes.

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